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  • Jen Fenner

New publication in iScience

Our newest manuscript titled: Evolutionarily conserved Wnt/Sp5 signaling is critical for anterior-posterior axis patterning in sea urchin embryos was published in iScience. In this study we explored the role of a deeply conserved gene sp5 in Anterior-Posterior patterning. We found that sp5 is critical for endomesoderm specification downstream of Wnt/b-catenin and is also necessary for anterior neuroectoderm patterning downstream of non-canonical Wnt/JNK signaling. Our findings in this study provide strong support for the idea that Wnt-Sp5 signaling cassettes were critical for the establishment of early germ layers in the common deuterostome ancestor.




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